KEGG   Homo sapiens (human): 10054
Entry
10054             CDS       T01001                                 
Symbol
UBA2, ACCES, ARX, HRIHFB2115, SAE2
Name
(RefSeq) ubiquitin like modifier activating enzyme 2
  KO
K10685  ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Drug target
Subasumstat: D12268
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    10054 (UBA2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    10054 (UBA2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.45  E1 ubiquitin-activating enzyme
     10054 (UBA2)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-activating enzymes (E1)
  UBL-activating enzymes
   10054 (UBA2)
SSDB
Motif
Pfam: ThiF UAE_UbL UBA2_C UBA_E1_SCCH NAD_binding_7
Other DBs
NCBI-GeneID: 10054
NCBI-ProteinID: NP_005490
OMIM: 613295
HGNC: 30661
Ensembl: ENSG00000126261
UniProt: Q9UBT2
Structure
Position
19:34428381..34471251
AA seq 640 aa
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
NT seq 1923 nt   +upstreamnt  +downstreamnt
atggcactgtcgcgggggctgccccgggagctggctgaggcggtggccgggggccgggtg
ctggtggtgggggcgggcggcatcggctgcgagctcctcaagaatctcgtgctcaccggt
ttctcccacatcgacctgattgatctggatactattgatgtaagcaacctcaacagacag
tttttgtttcaaaagaaacatgttggaagatcaaaggcacaggttgccaaggaaagtgta
ctgcagttttacccgaaagctaatatcgttgcctaccatgacagcatcatgaaccctgac
tataatgtggaatttttccgacagtttatactggttatgaatgctttagataacagagct
gcccgaaaccatgttaatagaatgtgcctggcagctgatgttcctcttattgaaagtgga
acagctgggtatcttggacaagtaactactatcaaaaagggtgtgaccgagtgttatgag
tgtcatcctaagccgacccagagaacctttcctggctgtacaattcgtaacacaccttca
gaacctatacattgcatcgtttgggcaaagtacttgttcaaccagttgtttggggaagaa
gatgctgatcaagaagtatctcctgacagagctgaccctgaagctgcctgggaaccaacg
gaagccgaagccagagctagagcatctaatgaagatggtgacattaaacgtatttctact
aaggaatgggctaaatcaactggatatgatccagttaaactttttaccaagctttttaaa
gatgacatcaggtatctgttgacaatggacaaactatggcggaaaaggaaacctccagtt
ccgttggactgggctgaagtacaaagtcaaggagaagaaacgaatgcatcagatcaacag
aatgaaccccagttaggcctgaaagaccagcaggttctagatgtaaagagctatgcacgt
cttttttcaaagagcatcgagactttgagagttcatttagcagaaaagggggatggagct
gagctcatatgggataaggatgacccatctgcaatggattttgtcacctctgctgcaaac
ctcaggatgcatattttcagtatgaatatgaagagtagatttgatatcaaatcaatggca
gggaacattattcctgctattgctactactaatgcagtaattgctgggttgatagtattg
gaaggattgaagattttatcaggaaaaatagaccagtgcagaacaatttttttgaataaa
caaccaaacccaagaaagaagcttcttgtgccttgtgcactggatcctcccaaccccaat
tgttatgtatgtgccagcaagccagaggtgactgtgcggctgaatgtccataaagtgact
gttctcaccttacaagacaagatagtgaaagaaaaatttgctatggtagcaccagatgtc
caaattgaagatgggaaaggaacaatcctaatatcttccgaagagggagagacggaagct
aataatcacaagaagttgtcagaatttggaattagaaatggcagccggcttcaagcagat
gacttcctccaggactatactttattgatcaacatccttcatagtgaagacctaggaaag
gacgttgaatttgaagttgttggtgatgccccggaaaaagtggggcccaaacaagctgaa
gatgctgccaaaagcataaccaatggcagtgatgatggagctcagccctccacctccaca
gctcaagagcaagatgacgttctcatagttgattcagatgaagaagattcttcaaataat
gccgacgtcagtgaagaagagagaagccgcaagaggaaattagatgagaaagagaatctc
agtgcaaagaggtcacgtatagaacagaaggaagagcttgatgatgtcatagcattagat
tga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (53)   
   RefSeq(nuc) (17)   
   GenBank (18)   
   EMBL (18)   
3D Structure (12)   
   PDB (12)   
Protein domain (5)   
   Pfam (5)   
All databases (114)   

Download RDF
DBGET integrated database retrieval system